Search results for "Biological complexity"

Networks in biological systems: An investigation of the Gene Ontology as an evolving network

2009

Many biological systems can be described as networks where diFFerent elements interact, in order to perform biological processes. We introduce a network associated with the Gene Ontology. Specifically, we construct a correlation-based network where the vertices are the terms of the Gene Ontology and the link between each two terms is weighted on the basis of the number of genes that they have in common. We analyze a filtered network obtained from the correlation-based network and we characterize its evolution over different releases of the Gene Ontology.

Topical issue on Ecological Complex Systems

2008

DOSE DEPENDENT SURVIVAL RESPONSE IN CHRONIC MYELOID LEUKEMIA UNDER CONTINUOUS AND PULSED TARGETED THERAPY

2010

A simulative study of cancer growth dynamics in patients affected by Chronic Myeloid Leukemia (CML), under the effect of a targeted dosedependent continuous or pulsed therapy, is presented. We have developed a model for the dynamics of CML in which thestochastic evolution of white blood cell populations are simulated by adopting a Monte Carlo approach. Several scenarios in the evolutionary dynamics of white blood cells, as a consequence of the efficacy of the different modelled therapies, pulsed or continuous, are described. The best results, in terms of a permanent disappearance of the leukemic phenotype, are achieved with a continuous therapy and higher dosage. However, our findings demon…